A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Daranide Side Effects, and Drug Interactions - Dichlorphenamide
Daranide Side Effects, and Drug Interactions - Dichlorphenamide
SIDE EFFECTS
Certain side effects characteristic
of carbonic anhydrase
inhibitors may occur with DARANIDE, particularly with increasing
doses.
The most common effects include gastrointestinal
disturbances (anorexia, nausea, and vomiting), drowsiness
and paresthesias.
Included in the listing which follows are some adverse reactions
which have not been reported with DARANIDE. However, pharmacological
similarities among the carbonic
anhydrase inhibitors
make it advisable to consider the following reactions when dichlorphenamide
is administered.
Central Nervous System/Psychiatric: ataxia, tremor,
tinnitus, headache, weakness, nervousness, globus
hystericus, lassitude,
depression, confusion, disorientation, dizziness;
Gastrointestinal: constipation,
hepatic insufficiency;
Metabolic: loss
of weight, metabolic acidosis,
electrolyte imbalance
(hypokalemia, hyperchloremia), hyperuricemia;
Hypersensitivity: skin
eruptions, pruritus,
fever;
Hematologic: leukopenia,
agranulocytosis,
thrombocy-topenia;
Genitourinary: urinary frequency, renal
colic, renal calculi,
phosphaturia.
DRUG INTERACTIONS
Caution is advised in patients receiving concomitant
high-dose aspirin and carbonic
anhydrase inhibitors,
as anorexia, tachypnea,
lethargy and coma have
been rarely reported due to a possible drug
interaction.
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