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Mircette Side Effects, and Drug Interactions - Desogestrel/Ethinyl Estradiol and Ethinyl Estradiol
SIDE EFFECTS
An increased risk of the following serious adverse reactions has been associated with the use of oral contraceptives (see WARNINGS section):
• Thrombophlebitis and venous |
• Cerebral hemorrhage |
thrombosis with or without embolism |
• Cerebral thrombosis |
• Arterial thromboembolism |
• Hypertension |
• Pulmonary embolism |
• Gallbladder disease |
• Myocardial infarction |
• Hepatic adenomas or benign liver tumors |
There is evidence of an association between the following conditions and the use of oral contraceptives: |
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• Mesenteric thrombosis |
• Retinal thrombosis |
The following adverse reactions have been reported in patients receiving oral contraceptives and are believed to be drug-related: |
|
• Nausea |
• Change in weight (increase or decrease) |
• Vomiting |
• Change in cervical erosion and secretion |
• Gastrointestinal symptoms (such as abdominal cramps and bloating) |
• Diminution in lactation when given immediately postpartum |
• Breakthrough bleeding |
• Cholestatic jaundice |
• Spotting |
• Migraine |
• Change in menstrual flow |
• Rash (allergic) |
• Amenorrhea |
• Mental depression |
• Temporary infertility after |
• Reduced tolerance to carbohydrates |
discontinuation of treatment |
• Vaginal candidiasis |
• Edema |
• Change in corneal curvature (steepening) |
• Melasma which may persist |
• Intolerance to contact lenses |
• Breast changes: tenderness, enlargement, secretion |
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The following adverse reactions have been reported in users of oral contraceptives and the association has been neither confirmed nor refuted: |
|
• Pre-menstrual syndrome |
• Erythema nodosum |
• Cataracts |
• Hemorrhagic eruption |
• Changes in appetite |
• Vaginitis |
• Cystitis-like syndrome |
• Porphyria |
• Headache |
• Impaired renal function |
• Nervousness |
• Hemolytic uremic syndrome |
• Dizziness |
• Acne |
• Hirsutism |
• Changes in libido |
• Loss of scalp hair |
• Colitis |
• Erythema multiforme |
• Budd-Chiari Syndrome |
Reduced efficacy and increased incidence of breakthrough bleeding and menstrual irregularities have been associated with concomitant use of rifampin. A similar association, though less marked, has been suggested with barbiturates, phenyl-butazone, phenytoin sodium, carbamazepine and possibly with griseofulvin, ampicillin, and tetracyclines (72).
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