A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Nasalcrom Overdose, Contraindications and Information - Cromolyn Sodium
Nasalcrom Overdose, Contraindications and Information - Cromolyn Sodium
OVERDOSE
There is no clinical
syndrome associated
with an overdosage of cromolyn sodium. Acute toxicity
testing in a wide variety
of species has demonstrated
an extremely low order
of toxicity for cromolyn
sodium, regardless of
whether administration was parenteral,
oral or by inhalation.
Parenteral administration in mice, rats, guinea pigs, hamsters and
rabbits demonstrated an LD50 in the region
of 4000 mg/kg. Intravenous administration
in monkeys also indicated a similar order
of toxicity. The highest dose
administered by the oral
route in rats and mice was 8000 mg/kg and at this dose
level no deaths occurred. By inhalation, even in long term
studies, it proved impossible to achieve toxic
dose levels of cromolyn
sodium in a range
of mammalian species.
CONTRAINDICATIONS
Gelatin Capsules and Inhalation Solution: Capsules and Inhalation
Solution are contraindicated in those patients who have shown hypersensitivity
to cromolyn sodium.
Capsules for Inhalation: Cromolyn sodium
is contraindicated in those patients who have shown hypersensitivity
to cromolyn sodium or
to lactose.
Inhalation Aerosol: Cromolyn sodium
inhaler is contraindicated
in those patients who have shown hypersensitivity
to cromolyn sodium or
other ingredients in this preparation.
Nasal Solution: Cromolyn sodium
nasal solution
is contraindicated in those patients who have shown hypersensitivity
to any of the ingredients.
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