A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Celebrex Overdose, Contraindications and Information - Celecoxib
Celebrex Overdose, Contraindications and Information - Celecoxib
OVERDOSE
Symptoms following acute
NSAID overdoses are usually
limited to lethargy, drowsiness, nausea,
vomiting, and epigastric
pain, which are generally
reversible with supportive care. Gastrointestinal bleeding
can occur. Hypertension, acute renal
failure, respiratory
depression and coma
may occur, but are rare. Anaphylactoid reactions have been reported
with therapeutic
ingestion of NSAIDs, and may occur following an overdose.
Patients should be managed by symptomatic
and supportive care following an NSAID
overdose. There are no specific
antidotes. No information
is available regarding the removal of celecoxib
by hemodialysis,
but based on its high degree of plasma
protein binding(³97%)
dialysis is unlikely
to be useful in overdose. Emesis and/or activated charcoal
(60 to 100 g in adults, 1 to 2 g/kg in children) and/or osmotic
cathartic may be indicated
in patients seen within 4 hours of ingestion
with symptoms or following a large overdose. Forced diuresis,
alkalinization of urine,
hemodialysis, or
hemoperfusion may not be useful due to high protein
binding.
CONTRAINDICATIONS
CELEBREX is contraindicated in patients with known hypersensitivity
to celecoxib.
CELEBREX should not be given to patients who have demonstrated
allergic-type reactions to sulfonamides.
CELEBREX should not be given to patients who have experienced asthma,
urticaria, or allergic-type reactions after taking aspirin
or other NSAIDs. Severe, rarely fatal,
anaphylactic-like reactions to NSAIDs
have been reported in such
patients (see WARNINGS - Anaphylactoid
REACTIONS, and PRECAUTIONS
- Preexisting Asthma).
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