A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Premarin Side Effects, and Drug Interactions - Estrogens Conjugated
Premarin Side Effects, and Drug Interactions - Estrogens Conjugated
SIDE EFFECTS
Tablets
See WARNINGS regarding induction
of neoplasia, adverse effects on the fetus, increased incidence
of gallbladder disease. The following additional adverse reactions
have been reported with estrogen
therapy.
- Genitourinary system: Changes in vaginal
bleeding pattern and
abnormal withdrawal
bleeding or flow. Breakthrough
bleeding, spotting. Increase in size of uterine
fibromyomata. Vaginal candidiasis. Change in amount of cervical
secretion.
- Breasts: Tenderness, enlargement.
- Gastrointestinal: Nausea, vomiting; abdominal
cramps, bloating; cholestatic jaundice.
- Skin: Chloasma or melasma
that may persist when drug
is discontinued; erythema
multiforme; erythema
nodosum; hemorrhagic
eruption; loss of scalp
hair; hirsutism.
- Eyes: Steepening of corneal curvature; intolerance
of contact lenses.
- CNS: Headache, migraine, dizziness; mental
depression; chorea.
- Miscellaneous: Increase or decrease in weight; reduced
carbohydrate tolerance; aggravation of porphyria; edema; changes
in libido.
Injection and Vaginal Cream
See WARNINGS regarding induction
of neoplasia, adverse effects on the fetus, increased incidence
of gallbladder disease, and adverse effects similar to those of
oral contraceptives, including
thromboembolism. The following additional adverse reactions have
been reported with estrogenic
therapy, including oral
contraceptives:
- Genitourinary System: Breakthrough bleeding, spotting,
change in menstrual flow; dysmenorrhea; premenstrual-like syndrome;
amenorrhea during and after treatment; increase in size of uterine
fibromyomata; vaginal candidiasis; change in cervical
erosion and in degree
of cervical secretion;
cystitis-like syndrome.
- Breasts: Tenderness, enlargement, secretion.
- Gastrointestinal: Nausea, vomiting, abdominal
cramps, bloating; cholestatic jaundice, pancreatitis.
- Skin: Chloasma or melasma
which may persist when drug is discontinued; erythema
multiforme; erythema
nodosum; hemorrhagic
eruption; loss of scalp
hair; hirsutism.
- Eyes: Steepening of corneal curvature; intolerance
to contact lenses.
- CNS: Headache, migraine, dizziness; mental
depression; chorea.
- Miscellaneous: Increase or decrease in weight; reduced
carbohydrate tolerance; aggravation of porphyria; edema; changes
in libido.
DRUG INTERACTIONS
See PRECAUTIONS.
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