A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Colbenemid Indications, Dosage, Storage, Stability - Probenecid and Colchicine
Colbenemid Indications, Dosage, Storage, Stability - Probenecid and Colchicine
INDICATIONS
For the treatment
of chronic gouty
arthritis when complicated
by frequent, recurrent acute
attacks of gout.
DOSAGE AND ADMINISTRATION
Therapy with probenecid
and colchicine should
not be started until an acute gouty
attack has subsided.
However, if an acute attack
is precipitated during therapy,
probenecid and colchicine
may be continued without changing the dosage,
and additional colchicine
or other appropriate
therapy should be given
to control the acute
attack.
The recommended adult
dosage is 1 tablet
of probenecid and
colchicine daily for one week, followed by 1 tablet
twice a day thereafter.
Some degree of renal
impairment may be
present in patients
with gout. A daily dosage
of 2 tablets may be adequate. However, if necessary, the daily dosage
may be increased by 1 tablet
every four weeks within tolerance (and usually not above 4 tablets
per day) if symptoms of
gouty arthritis are not
controlled or the 24 hour uric
acid excretion
is not above 700 mg. As noted,
probenecid may not
be effective in chronic
renal insufficiency particularly
when the glomerular
filtration rate
is 30 mL/minute or less.
Gastric intolerance
may be indicative of overdosage, and may be corrected by decreasing
the dosage.
As uric acid
tends to crystallize out of an acid
urine, a liberal fluid
intake is recommended, as well as sufficient sodium
bicarbonate (3 to
7.5 g daily) or potassium
citrate (7.5 g daily)
to maintain an alkaline
urine (see PRECAUTIONS).
Alkalization of the urine
is recommended until the serum
urate level returns to
normal limits and tophaceous
deposits disappear, i.e., during the period
when urinary excretion
of uric acid
is at a high level. Thereafter, alkalization of the urine
and the usual restriction of purine-producing foods may be somewhat
relaxed.
Probenecid and colchicine
(or probenecid) should be continued at the dosage that will
maintain normal serum
urate levels. When acute
attacks have been absent for six months or more and serum
urate levels remain within
normal limits, the daily dosage
of probenecid and
colchicine may be
decreased by 1 tablet
every six months. The maintenance dosage
should not be reduced to the point
where serum urate
levels tend to rise.
HOW SUPPLIED
Probenecid and Colchicine Tablets, USP 500 mg-0.5 mg
are bisected, white, capsule-shaped tablets imprinted “DAN DAN”
and “5325” supplied in bottles of 100 and 1000.
Dispense in well-closed, light-resistant container
with child-resistant closure.
Store at controlled room
temperature 15-30°
C (59-86° F).
Protect from light.
CAUTION: Federal law
prohibits dispensing without prescription.
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