A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Colbenemid Online, Description, Chemistry, Ingredients - Probenecid and Colchicine
Colbenemid Online, Description, Chemistry, Ingredients - Probenecid and Colchicine
DESCRIPTION
Probenecid and Colchicine contains probenecid, which is a uricosuric
agent, and colchicine, which has antigout activity, the mechanism
of which is unknown.
Probenecid is the generic
name for 4-[(dipropylamino)sulfonyl] benzoic acid. The molecular
formula is C13H19NO4S
and its molecular weight
is 285.36.
Probenecid is a white
or nearly white, fine, crystalline
powder. It is soluble
in dilute alkali, in alcohol,
in chloroform, and in acetone; it is practically insoluble
in water and in dilute
acids.
Colchicine is an alkaloid
obtained from various species
of Colchicum. The chemical
name for colchicine
is (S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]
heptalen-7-yl) acetamide. The molecular formula
is C22H25NO6 and its molecular
weight is 399.44.
Colchicine consists of pale yellow
scales or powder; it darkens on exposure to light. Colchicine is
soluble in water, freely
soluble in alcohol
and in chloroform, and slightly soluble
in ether.
Each tablet for oral
administration
contains 500 mg of probenecid
and 0.5 mg of colchicine.
Each tablet also contains
the following inactive ingredients: colloidal silicon
dioxide, magnesium
stearate, microcrystalline cellulose, sodium
lauryl sulfate and sodium
starch glycolate.
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