Cocaine Pharmacology, Pharmacokinetics, Studies, Metabolism - Cocaine

Cocaine Pharmacology, Pharmacokinetics, Studies, Metabolism - Cocaine

CLINICAL PHARMACOLOGY

Cocaine blocks the initiation or conduction of the nerve impulse following local application, thereby effecting local anesthetic action. Cocaine is absorbed from all sites of application, including mucous membranes and gastrointestinal mucosa. Cocaine is degraded by plasma esterases, with the half-life in the plasma being, approximately one hour.