A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Cocaine Side Effects, and Drug Interactions - Cocaine
Cocaine Side Effects, and Drug Interactions - Cocaine
SIDE EFFECTS
Adverse reactions may be due to high plasma levels as a result
of excessive and rapid absorption of the drug. Reactions are systemic
in nature and involve the central nervous system and/or the cardiovascular
system. A small number of reactions may result from hypersensitivity,
idiosyncrasy or diminished tolerance on the p.r. of the patient.
CNS reactions are excitatory and/or depressant, and may be characterized
by nervousness, restlessness and excitement. Tremors and eventually
clonicotonic convulsions may result. Emesis may occur. Central stimulation
is followed by depression, with death resulting from respiratory
failure. Small doses of cocaine slow the heart rate, but after moderate
doses, the rate is increased due to central sympathetic stimulation.
Cocaine is pyrogenic, augmenting heat production in stimulating
muscular activity and causing vasoconstriction which decreases heat
loss. Cocaine is known to interfere with the uptake of norepinephrine
by adrenergic nerve terminals, producing sensitization to catecholamines,
causing vasoconstriction and mydriasis. Cocaine causes sloughing
of the corneal epithelium, causing clouding, pitting, and occasionally
ulceration of the cornea. The drug is not meant for ophthalmic use.
DRUG INTERACTIONS
No information provided.
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