A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Catapres-TTS Overdose, Contraindications and Information - Clonidine Patch
Catapres-TTS Overdose, Contraindications and Information - Clonidine Patch
OVERDOSE
If symptoms of overdosage occur, remove all clonidine film
systems. The signs and symptoms of clonidine overdosage include
hypotension, bradycardia, lethargy, irritability, weakness, somnolence,
diminished or absent reflexes, miosis, vomiting
and hypoventilation. With large overdoses, reversible
cardiac conduction defects or arrhythmias, apnea, seizures and transient
hypertension have been reported. The oral
LD50 of clonidine in rats was 465 mg/kg, and in mice
206 mg/kg.
The general treatment
of clonidine film overdosage
may include intravenous fluids as indicated. Bradycardia can be
treated with intravenous
atropine sulfate and hypotension
with dopamine infusion
in addition to intravenous
fluids. Hypertension associated with overdosage has been treated
with intravenous furosemide or diazoxide
or alpha-blocking agents such as phentolamine. Tolazoline, an alpha-blocker,
in intravenous doses
of 10 mg at 30-minute intervals,
may reverse clonidine's effects if other efforts fail. Routine hemodialysis
is of limited benefit, since a maximum
of 5% of circulating clonidine is removed.
In a patient who ingested
100 mg clonidine hydrochloride,
plasma clonidine levels
were 60 ng/ml (1 hour), 190 ng/ml (1.5 hours), 370 ng/ml (2 hours)
and 120 ng/ml (5.5 and 6.5 hours). This patient
developed hypertension
followed by hypotension, bradycardia, apnea, hallucinations, semicoma,
and premature ventricular contractions. The patient
fully recovered after intensive
treatment.
CONTRAINDICATIONS
Clonidine film should
not be used in patients with known hypersensitivity to clonidine
or to any other component
of the adhesive layer
of the therapeutic system.
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