A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Cipro Overdose, Contraindications and Information - Ciprofloxacin
Cipro Overdose, Contraindications and Information - Ciprofloxacin
OVERDOSE
In the event of acute overdosage, reversible renal toxicity
has been reported in some cases. The stomach should be emptied by inducing vomiting
or by gastric lavage. The patient should be carefully observed and given supportive
treatment, including monitoring of renal function and administration of magnesium
or calcium containing antacids which can reduce the absorption of ciprofloxacin.
Adequate hydration must be maintained. Only a small amount of ciprofloxacin
(< 10%) is removed from the body after hemodialysis or peritoneal dialysis.
Single doses of ciprofloxacin were relatively non-toxic via
the oral route of administration in mice, rats, and dogs. No deaths occurred
within a 14-day post treatment observation period at the highest oral doses
tested; up to 5000 mg/kg in either rodent species, or up to 2500 mg/kg in the
dog. Clinical signs observed included hypoactivity and cyanosis in both rodent
species and severe vomiting in dogs. In rabbits, significant mortality was seen
at doses of ciprofloxacin > 2500 mg/kg. Mortality was delayed in these animals,
occurring 10-14 days after dosing.
In mice, rats, rabbits and dogs, significant toxicity including
tonic/clonic convulsions was observed at intravenous doses of ciprofloxacin
between 125 and 300 mg/kg.
CONTRAINDICATIONS
CIPRO (ciprofloxacin hydrochloride) is contraindicated in persons
with a history of hypersensitivity to ciprofloxacin or any member of the quinolone
class of antimicrobial agents.
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