A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Keflex Side Effects, and Drug Interactions - Cephalexin
Keflex Side Effects, and Drug Interactions - Cephalexin
SIDE EFFECTS
Gastrointestinal Symptoms of pseudomembranous colitis
may appear either during or after antibiotic treatment. Nausea and vomiting
have been reported rarely. The most frequent side effect has been diarrhea.
It was very rarely severe enough to warrant cessation of therapy. Dyspepsia,
gastritis, and abdominal pain have also occurred. As with some penicillins and
some other cephalosporins, transient hepatitis and cholestatic jaundice have
been reported rarely.
Hypersensitivity Allergic reactions in the form of rash,
urticaria, angioedema, and, rarely, erythema multiforme, Stevens-Johnson syndrome,
or toxic epidermal necrolysis have been observed. These reactions usually subsided
upon discontinuation of the drug. In some of these reactions, supportive therapy
may be necessary. Anaphylaxis has also been reported.
Other reactions have included genital and anal pruritus, genital
moniliasis, vaginitis and vaginal discharge, dizziness, fatigue, headache, agitation,
confusion, hallucinations, arthralgia, arthritis, and joint disorder. Reversible
interstitial nephritis has been reported rarely. Eosinophilia, neutropenia,
thrombocytopenia, and slight elevations in AST and ALT have been reported.
DRUG INTERACTIONS
In healthy subjects given single 500 mg doses of cephalexin and metformin, plasma metformin
Cmax and AUC increased by an average of 34% and 24%, respectively, and metformin renal
clearance decreased by an average of 14%. No information is available about the interaction of
cephalexin and metformin following multiple dose administration.
As with other β-lactams, the renal excretion of cephalexin is inhibited by probenecid.
Broad-spectrum antibiotics should be prescribed with caution in individuals with a history of
gastrointestinal disease, particularly colitis.
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