A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Cefzil Side Effects, and Drug Interactions - Cefprozil
Cefzil Side Effects, and Drug Interactions - Cefprozil
SIDE EFFECTS
The adverse reactions to cefprozil are similar to those observed with
other orally administered cephalosporins. Cefprozil was usually well tolerated
in controlled clinical trials.
Approximately 2% of patients discontinued cefprozil therapy due to adverse
events.
The most common adverse effects observed in patients treated with cefprozil
are:
Gastrointestinal: Diarrhea (2.9%), nausea
(3.5%), vomiting (1%) and abdominal
pain (1%).
Hepatobiliary: Elevations of AST
(SGOT) (2%), ALT (SGPT) (2%),
alkaline phosphatase
(0.2%), and bilirubin values
(<0.1%). As with some penicillins and some other cephalosporin
antibiotics, cholestatic jaundice has been reported rarely.
Hypersensitivity: Rash (0.9%), urticaria
(0.1%). Such reactions have been reported more frequently in children
than in adults. Signs and symptoms usually occur a few days after initiation
of therapy and subside within a few days after cessation of therapy.
CNS: Dizziness (1%). Hyperactivity, headache, nervousness,
insomnia, confusion, and somnolence
have been reported rarely (<1%). All were reversible.
Hematopoietic: Decreased leukocyte
count (0.2%), eosinophilia (2.3%).
Renal: Elevated BUN
(0.1%), serum creatinine
(0.1%).
Other: Diaper rash
and superinfection
(1.5%), genital pruritus and vaginitis
(1.6%). The following adverse events, regardless of established causal
relationship to cefprozil have been rarely reported during post-marketing
surveillance: anaphylaxis, angioedema, colitis
(including pseudomembranous colitis), erythema
multiforme, fever, serum-sickness like reactions. Stevens-Johnson Syndrome
and thrombocytopenia.
Cephalosporin Class Paragraph
In addition to the adverse
reactions listed above which have been observed in patients treated with
cefprozil, the following adverse reactions and altered laboratory tests
have been reported for cephalosporin-class antibiotics.
Aplastic anemia, hemolytic
anemia, hemorrhage, renal dysfunction,
toxic epidermal necrolysis, toxic
nephropathy, prolonged prothrombin
time, positive Coombs' test, elevated LDH, pancytopenia, neutropenia,
agranulocytosis.
Several cephalosporins have been implicated in triggering seizures, particularly
in patients with renal impairment,
when the dosage was not reduced.
(See DOSAGE AND ADMINISTRATION
and OVERDOSAGE.) If seizures associated
with drug therapy occur, the
drug should be discontinued.
Anticonvulsant therapy can be given if clinically indicated.
DRUG INTERACTIONS
Nephrotoxicity has been reported following concomitant
administration of aminoglycoside
antibiotics and cephalosporin
antibiotics. Concomitant administration of probenecid
doubled the AUC for cefprozil.
The bioavailability of the capsule
formulation of cefprozil was not affected when administered 5 minutes
following an antacid.
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