A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Claforan Online, Description, Chemistry, Ingredients - Cefotaxime
Claforan Online, Description, Chemistry, Ingredients - Cefotaxime
DESCRIPTION
Sterile CLAFORAN® (cefotaxime sodium) is a semisynthetic, broad spectrum
cephalosporin antibiotic
for parenteral administration. It is the sodium
salt of 7-[2-(2-amino-4-thiazolyl)
glyoxylamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo [4.2.0] oct-2-ene-2-carboxylate
72 (Z)-(o-methyloxime), acetate (ester). CLAFORAN contains
approximately 50.5 mg (2.2 mEq)
of sodium per gram of cefotaxime
activity. Solutions of CLAFORAN range
from very pale yellow to light
amber depending on the concentration
and the diluent used. The
pH of the injectable
solutions usually ranges from 5.0 to 7.5.
CLAFORAN is supplied as a dry powder
in conventional and ADD-Vantage® System compatible
vials, infusion bottles,
pharmacy bulk package bottles, and as a frozen, premixed, iso-osmotic
injection in a buffered diluent
solution in plastic
containers. CLAFORAN, equivalent to 1 gram
and 2 grams cefotaxime, is supplied as frozen, premixed, iso-osmotic injections
in plastic containers. Solutions
range from very pale yellow
to light amber. Dextrose Hydrous,
USP has been added to adjust osmolality (approximately 1.7 g and 700 mg
to the 1 g and 2 g cefotaxime dosages, respectively). The injections are
buffered with sodium citrate
hydrous, USP. The pH is adjusted
with hydrochloric acid and may
be adjusted with sodium hydroxide.
The plastic container
is fabricated from a specially designed multilayer plastic (PL 2040).
Solutions are in contact with
the polyethylene layer
of this container and can
leach out certain chemical
components of the plastic in very small amounts within the expiration
period. The suitability of the plastic
has been confirmed in tests in animals according to the USP biological
tests for plastic containers,
as well as by tissue culture
toxicity studies.
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