Cancidas Overdose, Contraindications and Information - Caspofungin acetate

Cancidas Overdose, Contraindications and Information - Caspofungin acetate

OVERDOSE

In clinical studies the highest dose was 100 mg, administered as a single dose to 5 patients. This dose was generally well tolerated. No overdosages have been reported. Caspofungin is not dialyzable. The minimum lethal dose of caspofungin in rats was 50 mg/kg, a dose which is equivalent to 10 times the recommended daily dose based on relative body surface area comparison.

In one 5-week study in monkeys at doses which produced exposures approximately 4 to 6 times those seen in patients treated with a 70-mg dose, scattered small foci of subcapsular necrosis were observed microscopically in the livers of some animals (2/8 monkeys at 5 mg/kg and 4/8 monkeys at 8 mg/kg); however, this histopathological finding was not seen in another study of 27 weeks duration at similar doses.

CANCIDAS is contraindicated in patients with hypersensitivity to any component of this product.