A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Cancidas Online, Description, Chemistry, Ingredients - Caspofungin acetate
Cancidas Online, Description, Chemistry, Ingredients - Caspofungin acetate
INTRAVENOUS INFUSION (not for IV Bolus Injection)
CANCIDAS®
(caspofungin acetate) FOR INJECTION
DESCRIPTION
CANCIDAS* is a sterile, lyophilized product for
intravenous (IV) infusion that contains a semisynthetic lipopeptide (echinocandin)
compound synthesized from a fermentation product of Glarea lozoyensis. CANCIDAS
is the first of a new class of antifungal drugs (glucan synthesis inhibitors)
that inhibit the synthesis of a (1,3)-D-glucan, an
integral component of the fungal cell wall.
CANCIDAS (caspofungin acetate) is 1-[(4R,5S)-5-[(2-aminoethyl)amino] -N2-(10,12-dimethyl-1-oxotetradecyl) -4-hydroxy-L-ornithine]-5-[(3R) -3-hydroxy-L-ornithine]
pneumocandin B0 diacetate (salt). In addition to the active ingredient
caspofungin acetate, CANCIDAS contains the following inactive ingredients: sucrose,
mannitol, acetic acid, and sodium hydroxide. Caspofungin acetate is a hygroscopic,
white to off-white powder. It is freely soluble in water and methanol, and slightly
soluble in ethanol. The pH of a saturated aqueous solution of caspofungin acetate
is approximately 6.6. The empirical formula is C52H88N10O15•2C2H4O2
and the formula weight is 1213.42. The structual formula is:
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