A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Soma Side Effects, and Drug Interactions - Carisoprodol
Soma Side Effects, and Drug Interactions - Carisoprodol
SIDE EFFECTS
Central Nervous System: Drowsiness and other CNS
effects may require dosage
reduction. Also observed: dizziness, vertigo, ataxia, tremor, agitation,
irritability, headache, depressive reactions, syncope, and insomnia. (See
WARNINGS: Idiosyncratic Reactions.)
Allergic or Idiosyncratic: Allergic or idiosyncratic reactions
occasionally develop. They are usually seen within the period
of the first to fourth dose in
patients having had no previous contact
with the drug. Skin rash, erythema
multiforme, pruritus, eosinophilia, and fixed drug eruption with cross
reaction to meprobamate
have been reported with carisoprodol. Severe reactions have been manifested
by asthmatic episodes, fever, weakness, dizziness, angioneurotic edema,
smarting eyes, hypotension, and anaphylactoid shock. (See WARNINGS:
Idiosyncratic Reactions.)
In case of allergic
or idiosyncratic reactions to carisoprodol, discontinue the drug
and initiate appropriate
symptomatic therapy, which
may include epinephrine, antihistamines, and in severe cases corticosteroids.
In evaluating possible allergic
reactions, also consider allergy to excipients (information on excipients
is available to physicians on request).
Cardiovascular: Tachycardia, postural
hypotension, and facial flushing.
Gastrointestinal: Nausea, vomiting, hiccup, and epigastric
distress.
Hematologic: Leukopenia, in which other drugs or viral
infection may have been responsible, and pancytopenia, attributed to phenylbutazone,
have been reported. No serious blood
dyscrasias have been attributed to carisoprodol.
DRUG ABUSE AND DEPENDENCE
In dogs, no withdrawal
symptoms occurred after abrupt cessation of carisoprodol from dosages
as high as 1 g/kg/day. In a study
in man, abrupt cessation of 100 mg/kg/day (about five times the recommended
daily adult dosage) was followed
in some subjects by mild withdrawal
symptoms such as abdominal cramps, insomnia, chilliness, headache, and
nausea. Delirium and convulsions did not occur. In
clinical use, psychological
dependence and abuse
have been rare, and there have been no reports of significant
abstinence signs. Nevertheless,
the drug should be used with
caution in addiction-prone individuals.
DRUG INTERACTIONS
No information provided.
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