A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Capozide Overdose, Contraindications and Information - Captopril and Hydrochlorothiazide
Capozide Overdose, Contraindications and Information - Captopril and Hydrochlorothiazide
OVERDOSE
Captopril
Correction of hypotension
would be of primary concern.
Volume expansion with an intravenous
infusion of normal
saline is the treatment
of choice for restoration
of blood pressure. While captopril
may be removed from the adult
circulation by hemodialysis,
there is inadequate data concerning the effectiveness
of hemodialysis for removing
it from the circulation of neonates or children. Peritoneal dialysis
is not effective for removing captopril; there is no
information concerning exchange
transfusion for removing
captopril from the general
circulation.
Hydrochlorothiazide
In addition to the expected
diuresis, overdosage of thiazides
may produce varying degrees of lethargy
which may progress to coma
within a few hours, with minimal
depression of respiration
and cardiovascular
function and without evidence
of serum electrolyte
changes or dehydration. The mechanism of thiazideinduced CNS
depression is unknown.
Gastrointestinal irritation and hypermotility
may occur. Transitory increase in BUN
has been reported, and serum
electrolyte changes may
occur, especially in patients with impaired renal function. In
addition to gastric
lavage and supportive therapy
for stupor or coma, symptomatic
treatment of gastrointestinal
effects may be needed. The degree
to which hydrochlorothiazide
is removed by hemodialysis has not been clearly established. Measures
as required to maintain hydration, electrolyte balance, respiration,
and cardiovascular
and renal function should be
instituted.
CONTRAINDICATIONS
Captopril
This product is contraindicated
in patients who are hypersensitive
to captopril or any other angiotensin-converting enzyme
inhibitor (e.g., a patient
who has experienced angioedema
during therapy with any other
ACE inhibitor).
Hydrochlorothiazide
Hydrochlorothiazide is contraindicated in anuria. It is also contraindicated
in patients who have previously demonstrated hypersensitivity
to hydrochlorothiazide or other sulfonamide-derived drugs.
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