A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Campath Online, Description, Chemistry, Ingredients - Alemtuzumab
Campath Online, Description, Chemistry, Ingredients - Alemtuzumab
Campath®
(Alemtuzumab)
WARNING
Campath should be administered under the supervision of a physician experienced in the use of antineoplastic therapy.
• Hematologic Toxicity: Serious and,in rare instances fatal, pancytopenia/ marrow hypoplasia,
autoimmune idiopathic thrombocytopenia, and autoimmune hemolytic anemia have occurred in patients receiving Campath
therapy. Single doses of Campath greater than 30 mg or cumulative doses greater than 90 mg per week should not be
administered because these doses are associated with a higher incidence of pancytopenia.
• Infusion Reactions: Campath can result in serious
infusion reactions. Patients should be carefully monitored during infusions
and Campath discontinued if indicated. (See DOSAGE
AND ADMINISTRATION.) Gradual escalation
to the recommended maintenance dose is required at the initiation of therapy
and after interruption of therapy for 7 or more days.
• Infections, Opportunistic Infections: Serious, sometimes fatal bacterial, viral, fungal, and protozoan infections have been reported in patients receiving Campath therapy. Prophylaxis directed against Pneumocystis carinii pneumonia (PCP) and herpes virus infections has been shown to decrease, but not eliminate, the occurrence of these infections. |
Campath® (Alemtuzumab) is a recombinant DNA-derived humanized monoclonal
antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein,CD52. CD52 is expressed on the
surface of normal and malignant B and T lymphocytes, NK cells, monocytes, macrophages, and tissues of the male
reproductive system. The Campath-1H antibody is an IgG1 kappa with human variable framework and constant regions,
and complementarity-determining regions from a murine (rat) monoclonal antibody (Campath-1G).The Campath-1H antibody has
an approximate molecular weight of 150 kD.
Campath is produced in mammalian cell (Chinese hamster ovary) suspension culture in a
medium containing neomycin. Neomycin is not detectable in the final product. Campath is a sterile, clear,
colorless, isotonic pH 6.8-7.4 solution for injection. Each single use ampoule of Campath contains 30 mg Alemtuzumab, 24.0 mg
sodium chloride,3.5 mg dibasic sodium phosphate,0.6 mg potassium chloride, 0.6 mg monobasic potassium phosphate, 0.3 mg
polysorbate 80, and 0.056 mg disodium edetate. No preservatives are added.
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