A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Wellbutrin Online, Description, Chemistry, Ingredients - Bupropion
Wellbutrin Online, Description, Chemistry, Ingredients - Bupropion
DESCRIPTION
ZYBAN (bupropion hydrochloride) Sustained-Release Tablets are a non-nicotine aid to
smoking cessation. ZYBAN is chemically unrelated to nicotine or other agents currently used in
the treatment of nicotine addiction. Initially developed and marketed as an antidepressant
(WELLBUTRIN® [bupropion hydrochloride] Tablets and WELLBUTRIN SR® [bupropion
hydrochloride] Sustained-Release Tablets), ZYBAN is also chemically unrelated to tricyclic,
tetracyclic, selective serotonin re-uptake inhibitor, or other known antidepressant agents. Its
structure closely resembles that of diethylpropion; it is related to phenylethylamines. It is (±)-1-
(3-chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride. The molecular
weight is 276.2. The molecular formula is C13H18ClNO.HCl. Bupropion hydrochloride powder is
white, crystalline, and highly soluble in water. It has a bitter taste and produces the sensation of
local anesthesia on the oral mucosa. The structural formula is:
ZYBAN is supplied for oral administration as 150-mg (purple), film-coated, sustained-release
tablets. Each tablet contains the labeled amount of bupropion hydrochloride and the inactive
ingredients carnauba wax, cysteine hydrochloride, hypromellose, magnesium stearate,
microcrystalline cellulose, polyethylene glycol, polysorbate 80 and titanium dioxide and is
printed with edible black ink. In addition, the 150-mg tablet contains FD&C Blue No. 2 Lake
and FD&C Red No. 40 Lake.
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