A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Betapace Online, Description, Chemistry, Ingredients - Sotalol Hydrochloride
Betapace Online, Description, Chemistry, Ingredients - Sotalol Hydrochloride
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To minimize the risk of induced arrhythmia, patients
initiated or re-initiated onBETAPACE AFTM should be
placed for a minimum of three days (on their maintenance dose) in a facility
that can provide cardiac resuscitation, continuous electrocardiographic
monitoring and calculations of creatinine clearance. For detailed instructions
regarding dose selection and special cautions for people with renal impairment,
see DOSAGE AND ADMINISTRATION. Sotalol
is also indicated for the treatment of documented life-threatening ventricular
arrhythmias and is marketed under the brand name BETAPACETM.
BETAPACE however, must not should not be substituted for BETAPACE AFTM
because of significant differences in labeling (i.e. patient package insert,
dosing administration and safety information).
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DESCRIPTION
BETAPACE AFTM, (sotalol hydrochloride), is an antiarrhythmic
drug with Class II (beta-adrenoreceptor blocking) and Class III (cardiac action
potential duration prolongation) properties. It is supplied as a white, capsule-shaped
tablet for oral administration. Sotalol hydrochloride is a white, crystalline
solid with a molecular weight of 308.8. It is hydrophilic, soluble in water,
propylene glycol and ethanol, but is only slightly soluble in chloroform. Chemically,
sotalol hydrochloride is d,l-N-[4-[l-hydroxy-2-[(l-methylethyl) amino]ethyl]phenyl]methane-sulfonamide
monohydrochloride. The molecular formula is
C12H20N2O3S·HCl
BETAPACE AFTM tablets contain the following
inactive ingredients: microcrystalline cellulose, lactose, starch, stearic acid,
magnesium stearate, and colloidal silicon dioxide.
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