A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Didrex Side Effects, and Drug Interactions - Benzphetamine
Didrex Side Effects, and Drug Interactions - Benzphetamine
SIDE EFFECTS
The following have been associated with the use of benzphetamine hydrochloride:
Cardiovascular
Palpitation, tachycardia,
elevation of blood
pressure. There have been isolated reports of cardiomyopathy
associated with chronic amphetamine
use.
CNS
Overstimulation, restlessness, dizziness,
insomnia, tremor,
sweating, headache; rarely, psychotic
episodes at recommended doses; depression
following withdrawal of the drug.
Gastrointestinal
Dryness of the mouth, unpleasant
taste, nausea, diarrhea,
other gastrointestinal disturbances.
Allergic
Urticaria and other allergic
reactions involving the skin.
Endocrine
Changes in libido.
DRUG ABUSE and DEPENDENCE
Benzphetamine is a controlled substance
under the Controlled Substance Act by the Drug Enforcement Administration
and has been assigned to Schedule III.
Benzphetamine hydrochloride
is related chemically and pharmacologically to the amphetamines. Amphetamines
and related stimulant drugs
have been extensively abused, and the possibility of abuse
of DIDREX Tablets should be kept in mind
when evaluating the desirability of including a drug
as part of a weight reduction
program. Abuse of amphetamines and related drugs may be associated with
intense psychological
dependence and severe social
dysfunction. There are reports of patients who have increased the dosage
to many times that recommended. Abrupt cessation following prolonged high
dosage administration
results in extreme fatigue
and mental depression; changes
are also noted on the sleep
EEG. Manifestations of chronic
intoxication with anorectic
drugs include severe dermatoses, marked insomnia,
irritability, hyperactivity, and personality
changes. The most severe manifestation
of chronic intoxication
is psychosis, often clinically
indistinguishable from schizophrenia.
DRUG INTERACTIONS
Hypertensive crises have resulted when sympathomimetic
amines have been used concomitanlly within14 days following use of monoamine
oxidase inhibitors. DIDREX
should not be used concomitantly with other CNS
stimulants.
Amphetamines may decrease the hypotensive
effect of antihypertensives.
Amphetamines may enhance the effects of tricyclic antidepressants.
Urinary alkalinizing agents increase blood
levels and decrease excretion of amphetamines. Urinary acidifying agents
decrease blood levels and increase
excretion of amphetamines.
top
