A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Benicar Online, Description, Chemistry, Ingredients - Olmesartan medoxomil
Benicar Online, Description, Chemistry, Ingredients - Olmesartan medoxomil
BENICAR™ Tablets (OLMESARTAN
MEDOXOMIL)
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USE IN PREGNANCY
When used in pregnancy during the second and third
trimesters, drugs that act directly on the renin-angiotensin system
can cause injury and even death to the developing fetus. When
pregnancy is detected, BENICAR™ should be discontinued
as soon as possible. See WARNINGS,
Fetal/Neonatal Morbidity and Mortality.
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DESCRIPTION
BENICAR™ (olmesartan medoxomil), a prodrug,
is hydrolyzed to olmesartan during absorption from the gastrointestinal tract.
Olmesartan is a selective AT1 subtype angiotensin II receptor antagonist.
Olmesartan medoxomil is described chemically as 2,3-dihydroxy-2-butenyl
4-(1-hydroxy-1-methylethyl)-2-propyl-1-[p-(o-1H-tetrazol-5-ylphenyl) benzyl]imidazole-5-carboxylate,
cyclic 2,3-carbonate.
Its empirical formula is C29H30N6O6 and its structural formula is:
Olmesartan medoxomil is a white to light yellowish-white powder
or crystalline powder with a molecular weight of 558.59. It is practically insoluble
in water and sparingly soluble in methanol. BENICAR™ is available
for oral use as film-coated tablets containing 5 mg, 20 mg, or 40 mg of olmesartan
medoxomil and the following inactive ingredients: hydroxypropylcellulose, lactose,
low-substituted hydroxypropylcellulose, magnesium stearate, microcrystalline
cellulose, talc, titanium dioxide, and (5 mg only) yellow iron oxide.
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