A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Tenormin Overdose, Contraindications and Information - Atenolol
Tenormin Overdose, Contraindications and Information - Atenolol
OVERDOSE
Overdosage with atenolol
has been reported with patients surviving acute doses as high as 5 grams.
One death was reported in a
man who may have taken as much
as 10 g acutely.
The predominant symptoms reported following atenolol
overdose are lethargy, disorder
of respiratory drive, wheezing, sinus
pause and bradycardia. Additionally,
common effects associated with overdosage of any beta-adrenergic blocking
agent and which might also be expected in atenolol
overdose are congestive heart
failure, hypotension, bronchospasm
and/or hypoglycemia.
Treatment of overdose should
be directed to the removal of any unabsorbed drug by induced
emesis, gastric lavage, or
administration of activated
charcoal. Atenolol can be removed from the general circulation
by hemodialysis. Other treatment modalities should be employed at the
physician's discretion and may include:
Bradycardia: Atropine intravenously. If there is no response
to vagal blockade, give isoproterenol
cautiously. In refractory cases,
a transvenous cardiac
pacemaker may be indicated.
Heart Block (Second or Third Degree): Isoproterenol or
transvenous cardiac
pacemaker.
Cardiac Failure: Digitalize the patient
and administer a diuretic. Glucagon has been reported to be useful.
Hypotension: Vasopressors such as dopamine or norepinephrine
(levarterenol). Monitor blood
pressure continuously.
Bronchospasm: A beta2 stimulant such as isoproterenol
or terbutaline and/or aminophylline.
Hypoglycemia: Intravenous glucose.
Based on the severity of symptoms, management may require intensive support
care and facilities for applying cardiac
and respiratory support.
CONTRAINDICATIONS
Atenolol is contraindicated in sinus
bradycardia, heart block
greater than first degree, cardiogenic
shock, and overt cardiac failure.
(See WARNINGS).
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