Tenormin Online, Description, Chemistry, Ingredients - Atenolol

Tenormin Online, Description, Chemistry, Ingredients - Atenolol

DESCRIPTION

Atenolol, a synthetic, beta₁-selective (cardioselective) adrenoreceptor blocking agent, may be chemically described as benzeneacetamide, 4 -[2'-hydroxy-3'-[(1- methylethyl) amino] propoxy]-.

Atenolol (free base) has a molecular weight of 266. It is a relatively polar hydrophilic compound with a water solubility of 26.5 mg/ml at 37°C and a log partition coefficient (octanol/water) of 0.23. It is freely soluble in 1N HCl (300 mg/ml at 25°C) and less soluble in chloroform (3 mg/ml at 25°C).

Tablets

Tenormin is available as 25, 50 and 100 mg tablets for oral administration.

Tenormin Inactive Ingredients: Magnesium stearate, microcrystalline cellulose, povidone, sodium starch glycolate.

I.V. Injection

Atenolol for parenteral administration contains 5 mg atenolol in 10 ml sterile, isotonic, citrate-buffered, aqueous solution. The pH of the solution is 5.5-6.5.

Tenormin Inactive Ingredients: Sodium chloride for isotonicity and citric acid and sodium hydroxide to adjust pH.