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Tylenol-Cod Side Effects, and Drug Interactions - Acetaminophen and Codeine
The most frequently observed adverse reactions include lightheadedness, dizziness, sedation, shortness of breath, nausea, and vomiting. These effects seem to be more prominent in ambulatory than in non-ambulatory patients, and some of these adverse reactions may be alleviated if the patient lies down. Other adverse reactions include allergic reactions, euphoria, dysphoria, constipation, abdominal pain, and pruritus.
At higher doses, codeine has most of the disadvantages of morphine including respiratory depression.
DRUG ABUSE AND DEPENDENCE
Acetaminophen and codeine phosphate tablets are a Schedule III controlled substance.
Acetaminophen with codeine phosphate oral solution USP is a Schedule V controlled substance.
Codeine can produce drug dependence of the morphine type and, therefore, has the potential for being abused. Psychic dependence, physical dependence and tolerance may develop upon repeated administration of this drug, and it should be prescribed and administered with the same degree of caution appropriate to the use of other oral narcotic-containing medications.
DRUG INTERACTIONS
Patients receiving other narcotic analgesics, antipsychotics, antianxiety agents, or other CNS depressants (including alcohol) concomitantly with this drug may exhibit an additive CNS depression. When such combined therapy is contemplated, the dose of one or both agents should be reduced.
The concurrent use of anticholinergics with codeine may produce paralytic ileus.
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