A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Aceon Online, Description, Chemistry, Ingredients - Perindopril erbumine
Aceon Online, Description, Chemistry, Ingredients - Perindopril erbumine
ACEON®
(perindopril erbumine) Tablets
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USE IN PREGNANCY
When used in pregnancy during the second and third trimesters,
ACE inhibitors can cause injury and even death to the developing fetus.
When pregnancy is detected, ACEON® Tablets should be discontinued
as soon as possible. See WARNINGS: Fetal/Neonatal Morbidity and Mortality.
|
DESCRIPTION
ACEON® (perindopril erbumine) Tablets is the tert-butylamine
salt of perindopril, the ethyl ester of a non-sulfhydryl angiotensin-converting
enzyme (ACE) inhibitor. Perindopril erbumine is chemically described as (2S,3a
S,7µS)-1-[(S)-N-[(S)-1-Carboxy-butyl]alanyl]hexahydro-2-indolinecarboxylic
acid, 1-ethyl ester, compound with tert-butylamine (1:1). Its molecular formula
is C19H32N2O5C4H11N.
Perindopril erbumine is a white, crystalline powder with a
molecular weight of 368.47 (free acid) or 441.61 (salt form). It is freely soluble
in water (60% w/w), alcohol and chloroform.
Perindopril is the free acid form of perindopril erbumine,
is a pro-drug and metabolized in vivo by hydrolysis of the ester group to form
perindoprilat, the biologically active metabolite.
ACEON® Tablets is available in 2 mg, 4 mg and 8 mg strengths
for oral administration. In addition to perindopril erbumine, each tablet contains
the following inactive ingredients: colloidal silica (hydrophobic), lactose,
magnesium stearate and microcrystalline cellulose. The 4 and 8 mg tablets also
contain iron oxide.
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