A1,
A2,
B,
C1,
C2,
D,
E,
F,
G-H,
I-K,
L,
M,
N,
O,
P1,
P2,
Q-R,
S,
T,
U-V,
W-Z
Precose Side Effects, and Drug Interactions - Acarbose
Precose Side Effects, and Drug Interactions - Acarbose
Digestive Tract
Gastrointestinal symptoms are the most common reactions to PRECOSE
®. In U. S. placebo-controlled
trials, the incidences of abdominal pain, diarrhea,
and flatulence were 19%,
31%, and 74% respectively in 1255 patients treated with PRECOSE ®
50-300 mg t.i.d., whereas the corresponding
incidences were 9%, 12%, and 29% in 999 placebo-treated patients. In
a one-year safety study, during which patients kept diaries of gastrointestinal
symptoms, abdominal pain
and diarrhea tended to return
to pretreatment levels over time, and the frequency
and intensity of flatulence
tended to abate with time. The
increased gastrointestinal
tract symptoms in patients treated
with PRECOSE ® are a manifestation
of the mechanism of action
of PRECOSE® and are related to the presence of undigested carbohydrate
in the lower GI tract. Rarely,
these gastrointestinal
events may be severe and might be confused with paralytic
ileus.
Elevated Serum Transaminase Levels
See PRECAUTIONS
Other Abnormal Laboratory Findings
Small reductions in hematocrit
occurred more often in PRECOSE ® -treated patients than in
placebo-treated patients but were not associated with reductions in hemoglobin.
Low serum calcium
and low plasma vitamin B6 levels were associated with PRECOSE ® therapy
but are thought to be either spurious
or of no clinical
significance.
Hypersensitive Skin Reactions
Rarely, hypersensitive skin reactions such as rash may occur.
Edema
In rare instances edema has been reported
DRUG INTERACTIONS
(See PRECAUTIONS - Drug Interactions
or CLINICAL PHARMACOLOGY - Drug-Drug Interactions )
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